Crohn’s Disease Explained

Crohn’s disease is a type of inflammatory bowel disease (IBD).

It is a chronic condition that causes inflammation of the digestive system. Crohn’s disease can affect any part of the digestive system, from the mouth to the anus.

The most common symptoms of Crohn’s disease are abdominal pain, diarrhea, and weight loss.
Crohn’s disease is an autoimmune disease, which means that the body’s immune system mistakenly attacks healthy cells.

Symptoms vary from person to person and can range from mild to severe symptoms.

It is important to seek medical help if you experience any of the symptoms of Crohn’s disease, as they can be quite serious.

The Causes of Crohn’s Disease

It’s always helpful to understand the background of a disease, and how it’s caused. This is more important when it comes to diseases like Crohn’s disease, where the exact cause is not known.
We do know that genetic factors play a role in who gets sick and who doesn’t. This is one reason why people with a family history of the condition are more likely to get it themselves.

But why does the disease occur? What causes it? The answers are complicated and involve several different causes. Here’s a brief explainer to help you understand the main factors that cause crohns disease.

The cause of Crohn’s disease is unknown, but it is believed to be caused by a combination of genetics and environmental factors.

There is no cure for Crohn’s disease, but there are treatments that can help control the symptoms. Treatment options include medications, surgery, and diet.


Characteristics of Crohn’s Disease

The most common symptoms are abdominal pain, diarrhea, and weight loss.

Some other symptoms can include rectal bleeding, fever, and joint pain.
Crohn’s disease is a lifelong disease and there is no known cure.

Treatment focuses on relieving symptoms and may include medications, surgery, and diet modifications.


The Most Common Symptoms of Crohn’s Disease


The most common symptoms are:

– Abdominal pain

– Diarrhea

– Rectal bleeding

– Weight loss

– Fever

– Fatigue

Many people with Crohn’s also experience symptoms outside of the gastrointestinal tract, such as:

– Joint pain

– Skin rashes

– Eye inflammation

– Feeling tired

– Feeling unwell

– Loss of appetite

– Weight Loss

– Fever

If you are experiencing any of these symptoms, it is important to see your doctor for diagnosis and treatment.

There is no one-size-fits-all treatment for Crohn’s disease, but there are a number of medications and therapies that can help control the symptoms.


Living with Crohn’s Disease


Living with Crohn’s disease can be emotionally challenging. Crohn’s is a chronic disease that can cause a great deal of pain and discomfort.

In addition, the emotional impact of Crohn’s can be significant. Crohn’s can cause feelings of isolation and depression.

It can be difficult to manage the disease and cope with the emotional challenges. There are a number of ways to cope with the emotional impact of Crohn’s disease.

It is important to have a strong support system. Friends and family can be a great source of support. It is also important to find a support group for people with Crohn’s disease. These groups can offer emotional support and practical advice.


What Is a Clinical Trial

A clinical trial is a research study in which people volunteer to test new treatments and therapies under the supervision of a doctor.

Clinical trials are the best way to determine whether a new treatment is safe and effective in treating an illness. Before a new treatment can be registered with a medical council, and used in the general population, it must be tested in a clinical trial.

During a clinical trial, volunteers are randomly assigned to one of two groups: the treatment group and the control group.

The treatment group receives the new treatment, while the control group receives a placebo or an existing treatment.

The goal of a clinical trial is to determine whether the new treatment is better than the control treatment. Volunteers in a clinical trial are closely monitored by doctors and nurses.

How to Participate in a Clinical Trial

When it comes to participating in a clinical trial, it’s important to be well-informed and understand the process. The first step is to find a clinical trial that may be a good fit for you.

You can do this by searching for clinical trials in South Africa and around the world.

Once you’ve found a trial that interests you, the next step is to contact the study coordinator to learn more about the trial and see if you’re eligible to participate.

To participate in a clinical trial, you must be in good health and meet the specific criteria for the trial.



What Happens During a Clinical Trial?


Phase 1:
Phase 1 clinical trials are the first step in testing a new drug or treatment. The goal of these trials is to figure out if the drug is safe.

In phase 1 clinical trials, the drug is given to a small number of healthy volunteers for a short period of time. This is the first time the drug has been given to humans, so the researchers are looking for any side effects the drug may cause.

Phase 2:
Phase 2 clinical trials are the next step in the clinical trial process, after a drug has been shown to be safe in phase 1 trials.

In phase 2 trials, Doctors test the drug on a larger group of people to see if it is effective in treating the condition it is meant to treat. They check for side effects, as well as the correct dose.

Phase 2 trials usually last for 6-12 months.


Phase 3:
Phase 3 clinical trials are the final step in a drug’s testing process before it is registered with a country’s medical council and made available to the public. These trials are designed to test the drug’s effectiveness and safety in a larger population, as well as to get a better sense of how the drug works in comparison to other available treatments.

Phase 3 clinical trials are typically randomized, controlled trials, meaning that patients are randomly assigned to receive the test drug or a placebo or a control drug that is already available on the market to treat a certain disease.

This helps to ensure that the results are not skewed by patient preferences or biases.

The trial also includes a “control” group, which typically receives the best available treatment for the condition being studied.

Phase 3 clinical trials usually last for several years.



Conclusion:  Contact the Experts

There is no cure for Crohn’s disease and patients will usually be required to take life-long treatment.

The symptoms may become less severe in some patients, but the condition can often flare up at any point.

It’s important to explore the many complementary therapies out there that can assist with Crohn’s disease.

As with any chronic illness, you will require to stay on top of your health, with the assistance of a qualified medical practitioner to guide you, at all times.

Dr George and Dr Deetlefs are clinical investigators at Spoke Research Inc and became involved in Clinical Research in 2017, and now runs the Inflammatory Bowel Disease trials.


If you’d like to take part in a clinical trial, join us here:

Apply for Crohn’s Disease Trial

Apply for Ulcerative Colitis Trial

We are here to provide you with expert medical advice in the field of clinical research with years of experience.

Contact us to find out more on clinical trials and treatment.


Medical surveys

Future treatments are now one step closer. 

Contact us

Spoke Research Inc
Mediclinic Milnerton,
Suite 109
Racecourse Rd, Milnerton
Cape Town


Mon – Thurs: 08:00-15:00
Fri: 08:00-12:00
Sat: Closed

Leave a Message

Privacy Agreement

7 + 4 =